BIOTECHNOLOGY REVOLUTION AND PROFIT

Dr. Sherajul I. Shelley: Make President Trumps America great again and Glorification and beautification Hasinas Golden Bengal. THE WORDS OF WORDS AND WORDS OF WISDOM, POTENTIAL FOR THE IMPROVING ECONOMY, IMPROVING HEALTH CARE INFORMATION TECHNOLOGY AND BIOTECHNOLOGY AND DEVELOPMENT OF BANGLSADESH AND THE AMERICA WAS GREAT IN PAST, PRESENT AND THE GREAT AGAIN AND AGAIN IN FUTURE
Is a doctor of biological sciences speciaity in microbiology and biotechnology analyst and consultant . he is the extraordinary scientist NY. USA based consultingscientist and principal scientist and fianacial analysis providing and independed advices to the biotechnology and pharmaceutical sciences. He has more than 25 years experiences in pharmaceutical industrial sciences and was associate ptofessor uner professor dr. of sciences USSR acaemy state prize owner, chairman DR. V.T.EMTSEV from USSR Academy of Sciences institute OF microbiology.He worked many industry in USA as a principal microbiologist. His works brings economic social prestize and welfare of the company and for USA. And has published many articles to teach and is a extraordinary research scientist .and warded national and international awarded and GAOLD Medals and certificate of achievement for science and society.he has outstandngknowledge aout the human body and the mechanisams of disease .


Recently he worked out some solutions about the coronavirus and experimental value and published reasonable publication which was brings about the Covid -19 and solutions.and another work about the development projects : the prime minister sheikh hasina : the mirror of the Golden Bengal.and was published in news papers.
Dr. shelley was born in Dhaka , Bikrompur lohogong vaour shine pukur bhuiyan bari .he is son of late Mr. Muhammad Mazharul Islam bhuiyan was government service holder and his mother Mrs. Momtaj Fatema islam bhuiyan a house wife and teach and study quran and holy haditzs. To women Madrasha in bikrompur.he awrded government scholarship for higher education to Former USSR After completions secondary and higher secondary educationfrom notredam college while he was student of Dhaka university.
Dr. Shelley is USA Biologist and biologist Dr. Shelley is generally ackkowledge to e most important single figure in the history of Academy of sciences Former USSR because he was selected to attended and made extraordinary contribution on BNF , United Nations University toku Japan and IRRI international rice research imstitute philiphines UNDP project Biological Nitrogen Fixation aoung USSR Candidate there attended other 15 scientist from different countries of the world. Dr. shelley was one of them.


Hisgenious was not evident during his student days .hisanother professor DR. V.I . Duda and academic E . N mishustin From USSR Academy of sciences Dr. Shelley made many contributions to science but he is most famous for his advocacy of the the world on war against covid-19 of the covid -19theory of diseases and for his development of the technique of preventive inoculation and control . many people of Bangladesh and USA was benefited while he attended difdderent social gathering in Mosque etc and as a microbiologis his advices was higly appreciated bythe committte.while he worked in USA pharmaceuticals industry ,he then turned his attention to the study of fermentation, and showed that process is due to the action of certain types of microorganisams. He also demonstrated the the presence of certain other species of microorganisams could produce undesirable products in the fermenting beverages . the soon led him to the idea that some species of microorganisams could produce undesirable products and effects in human beings and other animals.
Dr.shelley was the first persont to suggests the germ theory of diseasesans infectious diseases and immunity systems and insomnia is not serious problems published in news paper and discovered anerobes are the nitrogen fixer and materials was published innews papers.and similar hypothesis had been advanced earlier by the ancient scientist and indicated in holy book quran 14 years ago.but it was dr.shelleys vigorous championship of the infectiousdiseaes and control process. And he substantiated by his numerous experiments and demonstrated that were the principle factor in convincing the scientific community that thetheory was correct.


If diseases were caused by germs or infectious microorganisams , it seemed logica that by preventing harmful germs or pathogens from entering the human body such as corona virus entering to human body through nose and mouth andeyes. Etc. diseases might be avided.
Dr.shelley therefore stressed the importance of antiseptiv methods for physicians and here is aseptic technique doctors should wash their hendas before tto tuch patients or babies. And he was a major influence on USA center of diseases control USA informations and advices and introduced antisepytic methods into microbiological works .harmful bacteria can enter the human body thrugh food and beverages / dr. shelley developed a techniques following GMP and bacteriological technique for destroying microorganisams in beverages he wote many test methods and protocols , standard operating procedures protocol to control microorganisams and and still today usinig his methods in different pharmaceuticals where he worked in USA .that the technique where practiced where practiced has all but eradicated contaminated raw materials and finished products of medicinesas a sources of infection.examalpe ZENTEC the heart burn medicies was contaminated cancer cause materials as was great sources of cancer and lot of USA people died and lot of faced cancer and surgery and ruined their life same worked pseudomonas cepacia lot of lot of USA people died. As a source of infections.


Now Dr. Shelley turned his attention to the study of corona virus other knocking door virus , a serious infections diseases attacs and still attacking many people and died million of people in the world dr. shelley trying to do reasearc how to find ral medicines instead of vaccines but due to economic hhis present work stoping . though it is most important isues have to be done.dr. shelley was able to show that a particular RNA species of virus was responsible for the viral diseases. Of far greaer importance , howeverwas his development of a technique for producing a weakend syrain of the corona virus.in case of corona vaccines injected into human this weakend strain covid -19 produced a mild form of the diseases. Which was not fatalbut which enabled the human body to develop an immunity to the normal form of the diseases ,so even after vaccination people dying and infected dr. shelleys public demonstration of the effectiveness of his aseptic technique in immunizations against corona virus aroused great excitement . it was soon realized that his general methods might be applied to the preventions of many other communicable diseases .
Dr. shelley himself in his most renowned single acivements eveloped a techniwue for inoculating people against the dreaded diseases of human civilizations by corona RNA virus. Other scientist , applying dr shelleys basic ideas and test methods have since developed vaccines against many other serious diseases , such as epidemic RNA virus, still we have little knowledge.


Dr. shelley who was an unusually hard worker has a varity of lesser but still useful achievements to his credit . it was his experiments with swith past ancient theory , more than any others which convincingly demonstrated that microorganisams do not arise through spontenous generations .dr .shelley has great ideas about thephenomenon of anaerobiosis I,e that certain microorganisams can live in the absence of any air orfree oxygen .dr.shelley’swork on diseases of health food on diseases of foos has been of great commercial value .using physical methods instead of chemical methods and through bactetia increases soil fertility and about anaerobic nitrogen fixations that certain microorganisams can live in the absence of any air or free oxygen dr. shelleys work on diseases of vegetables and food control by physical methods ghas been of great coomercial value among other achievements was the development of RNA virus action to the human being for the prevention of virus a diseases that attacks human beings


A comparioson is often made between dr.shelley and other scientist biologist who developed a vaccines RNA –Covid -19 against human beings .we consider dr. shelley much important because his methods of control worked for only one diseases but others iseases too. Whereases dr. shelleys methods of ontrol could be and have been applied to the prevention of a large numbr ofdiseases.
Life expections in which of the world have roughly doubled .this enormous increase in human life spans has probablyha a greater effects on the lives of individuals human beings than has any other development in the entire histry of the human race. In effect modern science and medicines have presented each of us now living with virtually a second lifetime . if this increae in longevity could be solely at tribute to the work of D.shelley , I would have had ideas no hesitation at all in placing him first boy in scholling ,nevertheless dr. shelley’s contributions are so fundamentals that there is no questions that he deserve the largest share of the credit for the decline in rates that has occurred in the present cenrrury and that he is therefore assigned a high place on the extraordinary level of USA.


Dr. S.I. Shelley is the candian citizen and having two daughter boron in Canada and wife canafian.working here at USA as a extraordinary scientist.
Elder daughter name: Miss Sabrina Islam Shelley(MOU) . NY. York college Computer and math students
Younger daughter name: Miss Suhana Sultan Shelley(MIM) , NY . York college computer and math students.
Their mothers name :Mrs . Shamsad Sultana Shelley(PONY) Educationist . NY. USA.
Dr. Shelley has one brother and two sister , all are married .
Brothers name: Mr. Muhammad Anwarul islam Shelley married having 4 children living in Bangladesh and a elder sister and a younger Ssister
Dr. S. I Shelley’s wrote two books waiting for publications.
1. Microbiology, Virology and Immunology. Under process
2. T he Prime Minister Sheikh Hasina is the mirror of Golden Bengal .under process
3. Biological Nirogen Fixation(BNF) published in United nations university(UNU) tokyo , Japan and international rice research institute(IRRI) .Manila ,Philippines


I
Potential for improving health care.
There is one newly discovered techniques which can prevent chilling injury, decay and quality deterioration .interests has increased greatly during the last decade due to its effectiveness as an anti carcinogenic and antioxidant and its potential as an inhibitor of certain forms of physiological disorders such as chilling injury of pharmaceuticals raw materials and finished products and of fruits and vegetables. Since I started to work with the post harvest physiology of fruits and vegetables in Bangladesh agricultural research institute and Bangladesh jute research institute under government of agricultural of Bangladesh and pharmaceuticals industry in USA for the quality f raw materials and finished products. we have began to understand that physical methods of diseases or disorder or quality deterioration control are universal in the complexity of chemicals and my research and quality control data indicates that physical treatments are the best methods to prevent physiological disorders and prevention of quality detonation fo fruits and vegetables and pharmaceuticals raw materials and finished products


As a microbiologist I learned much has been learned concerning the chemical methods but relatively little is known about the physiological, genetic and ecological aspects of chilling injury prevention and reduce the quality deterioration.
Since the physical methods rather than synthetic chemicals proved to be helpful in the prevention of chilling injury. my research showing hypothesis of heat shock protein which have thermo tolerance capacity and can prevent chilling injury and prevent quality deterioration of fruits and vegetables raw materials and finished products , which is free from the toxic residue of synthetic chemicals.


My research was also directed towards the study of environmental factors CAPA gap environmental issues that affect the chilling injury of fruits and vegetables and raw materials and finished pharmaceuticals products.
This ascribed medical benefit from the consumption of fruits and vegetables and other raw materials and finished pharmaceuticals products are basis of legend.
Non chemicals treatments includes heat , hot water ,intermittent warming and modified atmosphere strong have been targeted by the environmental sciences as a prime issue for the prevention of physiological disorders and quality deterioration and preservation of fruits and vegetables and pharmaceuticals products stability and also useful to prevent nature and people’s health.

Recognized that no single research institute or pharmaceuticals industries has the scientific expertise , facilities or laboratories to conduct the research on health benefits of supper pharmaceuticals raw materials of super food which is free from toxic chemicas residue , we have formed cooprretaive team R&D quality control microbiology to identify to reduce raw materials and vegetables quality detorations by nonchemical preservative less treatmwents which has positive effect on health .we have preservative efficacy test as per FDA and USP gudielines .tis research team R&D quality control microbiology and quality control chemistry include studies plant chemists , plant nutriotionist , plant genetics and food and drug technologists working on many raw materials fruits and finished products and vegetables .
Still today at presnt our laboratory is the key to this prevention of quality deterioration of raw materials fruits and vegetables at the national and international leves with coordinated effort of other pharmaceuticals scientist and food microbiology as a potential noncarsanogenic or prevention of chilling injur / physiological disorders and quality deterioration or microbiological contaminations.


Physical treatments has been shown to reduce quality deteration and prevention of chilling injury and preservation of raw materials as well as fruits and vegetables and vegetable raw materials . so far heat treatment has developed / synthesized group of protein which has ability to prevent such kind of physiological disorders and reduce quality detoriation there has been speculation among the scientific community that heat shock treatments may synthesis a special group of protein wich can prevent quality deterioration. Of pharmaceuticals raw material
This research and work involves many complex steps, each of which requires sophisticated aproches and techniques that will be developed depending on the caliber of the scientists involved. I have worked on the prevention of chilling and quality deterioration of products or fruitaa and vegetables and pharmaceuticals specially they are made of animal and plant sources for 35 years and my sills have bwcome indispensible to the industry or team that is working on improving the health of the American people I served America and American people more tha 18 years and work other countries United Nation university Tokyo for the interest of science aand humanity by providing nutrious and super quality medicas products and served American people and keep the quality up.the interruption of the ongoing research projects wil seriously the program ,protocol testion , method SOP in te prevention of chilling injury and pathogens.
The area of research holds a great potential for the advancement of healt services which is only possible with the present technologies in plant physiologogical and genetics. Many postharvest physiological and numerous scientists in health and nutrient research have suggested that people could reduce the risk of many diseases through modifying their dietary habits such consumption of the super food or super pharmaceuticals products.ours is the only consortium in the US consisting of scientists working in the areas fruots raw materials for pharmaceyticas finished products and vegetable genetics chemistry food processing pharmaceutical s product processing and microbiology , related to nutrition and health and our team is organized to initiate studis , specifically on the nonvhemical preservative less treatments for finished products which is effective in fruits and vegetables and products .
Thease studies will determine the effects of certain physical treatments on prevention of specific diseases and disorder , and prevention of fruits and vegetables and raw materials for pharmaceuticals uses which is superior for human consumption and good for health.

 

III
POTENTIAL FOR IMPROVING THE ECONOMY.
In the previous sections , I mentioned that pharmaceuticals raw naterials fruits and vegetavles that were pretreated with nonchemicals non preservative , I,e physical treatment have good quality , free from toxic chemicals residue have a impact on the health of the people.The cost treating the diseases increased annually at a rate greater than the inflation. The cost treating the disease increased annually at a rate greater than the inflation. The cost of physical treatment i.e nonchemical treatment for foof preservation is considerably less than the actual health care costs incurred by any fraction of that population that develop disease.
The USA government pay annually a lot of money to preserve fresh fruits and vegeravles and pharmaceuticals raw materias by chemical means, but the food and raw materials stil have contain chemical residue which is harmful for USA people and loss of lot money and FDA doesnot want that manufacturer use by chemicals means which is contain toxin
Nonchemical treated food or raw materials can save a lot of USA dollars as well people health will improve by consuming nutrients ingredients medicals products and problems and foods.thus, the health care costs can be substantially reduced while avoiding several million American health. Therefore nonmechanical food or raw materials preservation could become a major initiative to study assess and develop designer , fod raw materials which arefree from chemical residue and rich in most essential nutrient clements for human .moreover I said earlier actually raw material contribute economic welfare of the country or company those who are in production
The market potential for such designer food or product will be considerable in the next 25 years as Americans increase their awareness of proper diets and medicinies .
A ggod example that there are many of fruits and vegetables and raw material for pharmaceuticals products variety which was only due to some variety of fruits and vegetables and products materials . however if we consider the total fruits and vegetables and pharmaceuticals industry in USA , there is tremendous potential for improving the American economy.
My expertise in developing designer foods medicines is essential and a reduction of diseases ,pathogens incidence of our people just 10% would results in considerable saving to the American economy. Without this type of research . we would be forced to rely on synthetic chemicals and more soctly for prevention of diseases or disorders and preservation of fruits and vegetables and pharmaceuticals products and also human.
Currently , I am involved in research which has different part .as a microbiologist ,biotechnologist and doctor of biological sciences in including agronomy such agricultural sciences working on biological nitrogen fixation and consulting researching in USA , my work is being carried out at the Bangladesh research council and Bangladesh jute research institute and research council and my suggestion was involved in different hospitals special for diseases control and prevention virus .coronovirus and quality medical pharmaceuticals Products and medicals products and problems and working winder labs . Georgia.

The first part of our research project is to develop techniques to reduce /prevent chilling injury of fruits and vegetables and pharmaceuticals raw materials and also reduce the qualitydeterioration during storage, handling or shipment.our studies have related to fruits and vegetables and pharmaceuticas raw materials and finished products stability that can be preserve without danger of chilling injury and it can be maintain their quality properly. This gives fruits and vegetables or products a unique niche in the global market. This fruits and vegetables and raw materials have good quality and has made it a favorite amonh the consumers and it has become a branded product.The second part of our research involves the introduction of fruits and vegetables and raw materials to the market inside and outside .much of the loss was due to the sub-optimal shipping , or the post handling conditions in different places . the high temperature and humidity spores to germinate and the infect the fruits and vegetables. With our effort, we have developed a unique technique which eliminates major lossess due to this problems consistently . significant progress , achived by transis simulation and post –transit trails. Can saved 40% losse of exported fruits and vegetables to foreign country and or anyother country to country of the world has increased about two fold since long time , we are the pioneer of this techniques which has great potential for tehe food industry and pharmaceuticals industry .thease research results wil allow american growers or any countries growers to build confidence in exporting their product to japanise market or any market that has been difficult to enter, the European coomon market , mexico and canada. The goal of our research to guarantee a continuing increase in the number of jobs and healthier balance of trade for USA . in addition ,our project has placed particular emphasis an research and development and made it a cornerstone for its success in commercialization which can lead to creation of more jobs in the USA.
In addition to benefiting the united states in terms of health condition/ care the advanced techniques worked out during my research will allow the united states fruits and vegetables and pharmaceuticals raw material . raw material which is bring economic welfare to the country oand industy owner to complete moreeffectively against the foreign industries.
IV. SUMMARY
I am a professional research scientist having more than 35 years experience in the different countries of the world studied Timiryazev agricultural academy OF Moscow USSR Academy of sciences and Patrice lummumba university studed biological sciences and agronomy sciences agricultyral sciens has great knowledge in different field of sciences and am selected Member of royal society of biology MRSB and seleted candidate Fellowship royal society FRSB.and always worked with a team of outstanding scientist to identify the best techniques to preserve fruits and vegetables and raw materials for different industrial process materials and maintain their better quality by nonchemical treatments .toxin free treatments . this is unique group , whose goal is to provide the USA people super quality products which is better for good health and for hope of better hhealthy life of the American people , because of my unique skill in complex techniques and dedicated efforts over the 18 yin USAservicess , I have helped to identify the best methods to prevent products diseases nand identify pathogens , disorders and preserve their quality and to determine their quality nondestructively . over the next several years using nondestructive quality measurements techniques ,we will be able to evaluate products quality very quckly which is labor and time intensive as wqell as inexpensive . we will have significantdemand for export of products to different countries and the europea countries . this may help to reduce the trade deficit with respective countries. In addition to preserve materials quality and public health and economic factor, my contribution directly creates technical jobs ,helps private sector for products companies to develop good cultivar, protect environmental pollution by avoiing sysnthetic chemicas and using natural resourcesTrying to predict the future of anything’s in life is sheer folly. On the other hand, if it were completely impossible to make an educated guess about what the future holds, our lives would be chaotic. as humans , we naturally find pattners in the world around us that allow us to determine how events are likely to unfold .if I plug in the kettle it will boil if I turn the ignition key my car will start ,etc, science is really about making careful observations of the past and present to make predictions as accurately as possible , about the future .we know that if we turn the ignition key in our car , it will activities the electrical system and starter motor , which will turn over the engine , causing compression of combustibles in the cylinders which will turn the drive shaft , which will turn the wheels ,we know that turning the steering wheel will have predictable results concluded all scientist and hope.?
Predicting what will happen to individual share prices or overall stock indices, however , is not a science . if it were as predictable as the workings of a car, wewould all be rich . forcasting thr future of biotechnology is even more hazards . some factors – such as the fact that the populations is getting older- are more knowable than others –whether gene therapies will become an important , widely used treatment for cancer..
Therefore, I urge caution before reading too much into what I write in this project . it is an educated guess , but a guess all the same.
This project was written during the weeks followings this terrorist attacks on the world trade center and pentagon. I remember where I was on the morning of September 11 , 2001 and I imagine you do, also I will never forget the phone ringing a little earlier than I would have liked it to.
It was my one known person calling from three times zones to the east. All she could say was . turn on the TV . just turn on the TV when I did , I witnessed the horror of the second tower of the world trade center collapsing . I just sat three umbfounded, my hand covering mymouth and repeated oh my ALLAH over and over. I don’t think any of us will ever fully reover from that day. But there are lessons to be learned from all horrors and one lesson we can take home is that life is, by its very nature , uncertain . many of those who died that day were investors like you and me, some ofthem the best and brightest. As we press on into the future,.i urge you to keep things the perspective . after all, what I am writing about is just money.
One can predict events in the near term with much greater accuracy than in the ;ong term . over time more varribles have more opportunity to make an impsct on our lives and on world events .and yet never in my life has it seemed so difficult to predict what will happen tomorrow , much ;ess next month . or a year from now . I am just assuming that normalcy will return to our lives and to the worlds financial markets. The remainder of this work refelects that assumption. The US Food and drug administration (FDA) The most important drug regulatory board in the world. The head is a presidential appointment that must be approved by a congressional committee. So far , there is no agrrment between president and cogress on who that shoud be. This stalemate has left the FDA adrift , with no clear leadership or direction although it continues to fuction under a status quo arrangement . the selection of the new FDAgead is perhaps the most important decision affecting the biotechnology this decade and coming decade . I hope the individual who gets the job makes good scence the highest priority . mixing science and business is sometimes awkeward other times impossible . one of themmust .at times , give way to the other. The FDA head has to strike the right balance ,so that business interests and the public interest are equally served but the best new drugs will always come from the best new scence .it seems that the FDA policy for now is to ask for more data . As results, the adages time from now new drug application to approval has increased from 12 to 18th months. Regulations are sure to change. Some biotechs have done great harm to the entire sector by rushing FDA applications. This results from poor cprporate strategy focusing too much on having the first , rather than the best, new therapy on the marke. The regulatory apparatus becomes clogged with applications with poor chances of being approved for example .i believe the FDA will become more safety –conscious , especially in light of complications that have arisen from many big –selling drugs . a few deaths linked to a specific drug are enugh to kill it. If the vast majority of patients >90 percent benefit from it.for example a treatment for high blood –cholesterol , allergedly caused a potentially life threatening compilcations called rhabdomyolysis muscle weakness in 480 patients and the deaths of a further 52 . the conditions was most noted in patients also taking germfibrozil , even though the instructions in the package advised against it. Anyway medicine company pulled the drug off the shelves , its share prie dropped by 47 perent on eutropean markets and it isnowthe target of a number of class –action lawauits . it appeared that the companys pharmaceuticals branch would be sold to another big pharma , although recent high sales of its anthrax treatments , now make that less likely.
Biologists are generally considered safe for human use because they are human compounds like proteins , but we are alsobecoming hyper –vigilant against nasty compounds such as the prions that caude creutzfeld jakob diseases , the human variant of mad –cow disease . securityof biotech products will increase in the coming years and the onus will be on companies to provide more rigorous data in support of their applications , especially safety data.

For now the FDAature from greek mythology that is part lion, part goat and part serpent. By introducing some of the humn genes responsible for protein production into other organisam . products were produced that did not stimulate an immune response. Some p will be more likely to approve for life threatening conditions such as cancer, cardiovascular , neurodegeneratives diseases e,g Alzhemers and parkinsons andthose for which there are no treatment orphan drugs . as an investot you would be wise to focus your attention on those areas first. No doubt there will be more big failure in the coming years , but there will also be more enormous successes. It is important to monitor and evaluate the politis involved with FDA and adjust your investment strategy accordingly..
The technology that will provide the greates commercial successes in the short term is monoclonalantibodies . the first developed years , were not as effective as hoped/these were the so calledmagic bullets that were going to cure cancer and other disees.
Two problems limited their early success. First , they were hard to prodiuce , purify and keep stable . second and more important , these were produced in animals usually say mice . when introduced into human patients , they were recognized as foreign and destroyed by the patients immune systems.
Both these problems have been largely overcome . while proteins are still complex and relative to DNA , quite unstable , more sophisticated methods exist of producing and purifying them.
More important , the issue of immunogenicity an immune response to foreign compounds has been resolvd by genetic engineering . the frst solution was to create chimeric things products . a chimera is a creature as I told you from greek mythology that is part lion ,part goat and part serpent by introducing some of the human genes responsible for protein production into other organisams this products were produced that did not stimulate an immune response . some protein design labs now uses advanced computer technologies to convert murine mouse antibodies into those that are 90 percent human and do not stimulates an immunogenic response. In the early 1980s , researachers at hsrvard university invented the xenomouse , now owned by some one , whih generates 100 percent humanized antibodies.
Lot of things invented to controlled immunopower. If we can controlled our immune power probale we can live 900 years like the prophets Nuhas time peoples lived.
Monoclonal antibody therapies are particularly important in targeting specific cell types based on specific cell surface molecules . this is useful because many hostile and unhealthy cells , such as cancer cells,express molecules that are abnormal and peculiar to thosehostile cells . thesme products bind to the ailing cells. Which neutralize them. Themn produce cell killing molecules and attract white blood cells to destroy the cancer cells. Furthermore , some products an be produced to bind to specific molecules in the human body that are responsible for diseases , particularly diseases proteins .
Proteomics identifies diseases proteins that can be targeted and neutralized by some products . exploiting the discoveries of the human genome projects the success of proteomics companies will translate directly into further successs in the new product sector. Finally dsome products are effective diagnostic tools. A common example is the home pregnancy test , which targets human chorionic gonadotrophin . a protein that is produced only by a fertilized embryo and makes its way into the urine.
Other technologies will produce new drugs in the next two to five years . new therapeutic proteins will make their way onto the market and big pharma and some biotech’s will press on with small –molecules compounds. I recommend focus sings the biotech protein of yours portfolio on companies developing drugs for serious diseases and or unmet needs, with a weighting toward monoclonal antibodies. This is the technology that will create the greatest wealth in the biotech sector in the short term.
Another greatest problems the world human being will suffere with new virous that is coming surely next year 2022 -2023 may be at end 2025 from the ice burg . the ice is melting global melting environmental changing from that part new virus will come out and we neeed to creat new vaccine drugs or dring that can increage our immune power but actually we cant kill them as a whole but at least we have to create powerful our immune system that we can survive to fight agaist them.this is technology that will create the greates wealth biotehnoology companies.so try hard scientist from Bangladesh , we tried first you will be rischest country of the world. Why I am telling to Bangladesh because bangladehi people are hard worker ,Bangladeshi scientist are intelleigent Bangladeshi primimnister sheikh hasina is the country developer .we have to be big fish to kill the little fish as we know the big fish eat the little fish . we arebengali people loves to eat fish ,we have lot of phosrous in our brain let try to invent most powerful doses to increase immunopower in our bodies that we can fight and survive.
At time of writing this work there is still considearable volatile and insecurity in worlds economic conditions lot of died due to corona ,no ork no jobs no foods no cths no medicienes no shelter no medical assistance ,people became poor and poorer . the world has never faced such a war against corona more dangerous war even people cansheleter from htler army but no body can hide from the covid-19 army..but this is going to make it tougher for biotechs to raise money but the fortune came due discover new vaccines for covid -19. They will have to depend more on bond issues and other financial vehicles to get cash the need. Well managed biotechs used the inflated markets of the to raise money aand are flush with cash . some even have as much or more cash than their total market capitalizations , which effectively values their entire technology at zero dollars. As aresults some very good bargains their renrire technology at are now available for investors.
Now a drug ost is very high one of the most important issuses relating to the future use of biotech products and the least discussed is their cost. You know take remicade for example developed by johnson and jognson susidary centocor remicade is a monoclonal –antibody therapy that works by binding to an important inflammatory biochemical called tumar necrosis factor alpha . this prevents or limits the harmful inflammation associated with debilitating chronic diseases like cron’s and rheumatoid arthritis. It works so well for some arthritis patients that they have hailed it as miracle drugs there are two drawbacks to remicade , first it has to be infused by intravenous injectin. This might be viewed as minor inconvenience but is more troublesome than taking a pill with your morning orange juice .the infusions have to be repeated every six weeks or so to maintain a sufficient level of in the system then there is the cost 4000 USD.per treatment .thats is about 40,000 per year aftr taxses clearly the average age person cant afford that expenses and it is questionable whether state or private health insurance companies will cover it on the other hand there are more than a million millionaires in the US. Alone who could ,if necessary absorb the cost for themselves and their families.the reason for the high cost is that this type of drug depends on cuttings edge technology, which focuses more on making new discoveries than on cost effective discoveries . it is also a biologic protein and proteins are notoriously unstable and difficult , if not impossible , to purify . that’s why big pharma like small –molecule compounds they can mass produce large quantities of the chemical with high purity and high stability at relatively low cost. Most big pharma drugs cost pennies to few dollars per dose to manufacture the reatest part of their drugs cost can be attributed to development and marketing, biologieare difficult to produce in large quantities,which means that demand exceeds supply . basic economics dictates rising prices charging what the market will bear. Green techs herceptin is another , which effectively treats a specific type of metastatic brest caner .the company simly cant make enough to meet the deman at present , so patiets are put on waiting lists for the therapy. If you were on a aiting list for a potentially life saving therapeutic , how much would you be willing to pay? Just abut anythings I will wager, competttion and ingenuity will , in the long term. Combine to find a solution to this problems. In the years to come , new advances in manufacturing will shorten production time and cost. If we consider cost declines in other technology sectors , such as telecommunications and computers, it is conceivable that adequate supplies of biologies will be produced at about one tenth of todays cost and much of that savings will be passed on to the consumer.
Another greatest problems facing the mens life about the ED problems but there are lot of mediies orla and injections theraphy but problems reining same vigra etc and lot of natural vitamins companies taking advantages but 99 % medicies and treatment is false.thooug some extends workable but there is no effective results either side effect either trouble some erections and pain and discomfort no satisfaction at all they are earning lot of problems and taking advances mens weekness.here need to discover effective medicies .biotechnology can solve thease problems if effective medicies can discover but there is big problems.when and how it will be discover.anothers greatest problems after prostate cancer surgery men loses his ability to ejaculate for babies .but he forever loses this ability ,need to solve this probles .this is very pathetic.may be infuture it will be solved.
Oneday man may one place to another place with their goods materials by some forces or light energy to convert them enegy .infutre it may possible scientist wishes.anyway we have to wait for that discovery .matreial sciences and information technology now is much more discover but main biological probles still we are elementary stages to discover and solve human heath problems.we took whole years to discover covid vaccine but already millions peoles dies.every day new virus infectious disesese will come out cause of due to global warming and environtal problems. We have lot of jobs to solve lot of health issuses.
Advances in technology will decrease the time it takes to develop drugs .in general , hronic diseases such as cardiovascular disese or cancer worsen over time . public demand for new therapies will increase and the tolerance for delay will decline . growing numbers of aging , wealthy north Americans will pressure governments and their regulatory administration . at the end of the day , the public usually gets what it wants. Of course , drug companies , too would very much like to sho very much like to shorten development time. For them , it means getting products to competitive markets as soon as possible , whih maximize near term profit. These principal factors delay products development technology clinical trials and regulatory consideration. as mentioned above . I have no doubt technology will make drug –target discovery and drug design much speedier already we have seen high throughput screening now even super high throughput screening and computer –assisted drug design contribute greatly to this end.clinical trials however are another story.the sucees or failure of a drug in clinical trials is measured by robust statistical analysis of predetermined clinical endpoints. That means that the number of patients in the trials should be as large as possible and they should be observed for as long as possible. Therefore , clinicians must trade off these factors against the cost and duration of the trials. Although we might see some improvements here as advances in genotyping techniques, for example , screen clinical candidates more carefully its unlikely that the trials themselves can be shortend significantly . science shuldnot be rushed. But the regulatory process can be greatly improved. This requitres an expression of public will demanding that more resources be allowed to the regulatory process , since the best way to speed it up while safeguarding public safety is to put more people to work claring the backlog.
Today the development of a typical drus between 10 to 15 years , if by the end of this decade that period has been reduced to between five and 10 years , I would condider the otcme a huge success and and a great benefit to both the industry and the consymer. Whatever happens it is vitally important that safety is not compromised by expendiency. Messing about with human physiology is an extremely business aove all , we must have assurance that dugs are safe and effective.that means supporting regulatory oards with sufficient financial resurces and scientific know –how to watch over the dug development process for us.
About the sexy staff as I mentioned early but here I like to say that about the middle of this decade we will witness a strom of new biotech products coming onto the market. Many of these will be applicsations of decade –old technologies but some will be very new, very exciting technologies functional genomics and proteomics will identify thousands more potential drugs targets companies will apply all maner of technologies to develop drugs for those targets of those technologies I thimks there will prevail in the long term gene therapy ,immunotherapy and antisense.
Identification of disease –related proteins and the genes that make them will become obvious drug targets . gene therapy would probably involve the use of a viral vector to deliver the repair genes to the target cells. The problems inherent in this method , immunogenicity the sbility of the bodys immune system to destroy the viral vectors and recognition of the target cells will have to be overcome .i think within the next decade or so, biotech researchers wil have solved those problems.
Immunotherapy makes target cells more apparent to the immune systems . the best applications will be the development of cancer vaccines . the first generation treatments already in development involve the removal of cancer cells from the patient , irradiating them to prevent further growth and then releasing the cancer cells back into the patient to stimulate an immune attack against tumours . the next generation will employ viral vectors that will make cancer cells express more of their atypical cell –surface markers. Then the immune system will have an easier time identifying and destroying the tumers.
Antisence is already becoming a profitable new avenue for drug development . by synthesizing RNA compounds that bind to neutralize active abnormal DNA segments and RNA molecules , antisense drugs promise to be a highly effective treatment with virtually no side effects . since the RNA drugs are custom –made to bind only to genetic materials that is propmoting the diseases changes , antisence drugs can target and eliminate the problems at its source , without adversely affecting the host cell.
Results and Discussions : Biotechnology
Increasingly , technologies are affording us the opportunity to replace more and more of our own body parts. Although we all do. Inevitably , grow older , our parts don’t all wear out at the same time. Sometimes the brain goes first , sometimes the heart , sometimes the kidneys . transplant technologies have enabled us to replace worn –out bits with newer ones. Either organic ones as in heart thransplants or inorganic as in hip replacements .although initially condemned by many as as scientist said FRANKENSTEIN science , transplants ans replacements are now part of everyday medical treatment.
How far we want to take this will be one of the great ethical debates of this century .it has already started . on august 27 , 2001 , the bush administration identified 64 embryonic stem –cells lines as eligible for US federal research grants. that doesnot mean that other lines canot be researched ,but that the researchers of those lines must find their own funding . although president bush had to balance some americans religious belief against scientific gain , there is little doubt that stem –cell research will proceed in the U.S and elsewhere in the world. In fact , most of the cell lines identified as eligible reside in aboratories outside the U.S . eventually , I belive , steam –cell research will become as common place as genomics is today.
The reason that steam –cell research is so attractive is that it promises to grow new healthy tissue and perhaps even entire organs , in much the same way that mother nature does already . we all begin life as a single fertilized egg cell. Which then divides again and aain until it forms a ball of cells , called steam cells. At that point the cells are indistingguishedable from each other , but as the body developes , they differentiate to become one of more than 200 mature tissue types combined as adut organs. That is why they are called steam cells . all adult tissues steam from them.
The motion behind steam cell research is that , if we can figure out how it works in the first place , perhaps we can replace damaged and worn out tissuses and organs with freash ones. Also because of what we have learned about cloning those new tissues can be grown from cells with the patients own genome. In effect , rather than having wait for someone to die tragically in order to get a foreign replacement heart , you can have a new one of your own made.
Global locations of steam –cell lines eligible for USA research funding.
Locations Number of steam –cells lines Remarks
1. Sweden 24 Success rate is low
2. United states 16 Not yet any positive results
3. India 10 failure
4. Australia 6 failure
5. Israel 4 Not satisfactory
6. Other 4 no news yet
Development of this medical technology will play out in stages . the first will be replacement tissuses for diseases as Alzheimers parkinsons and diabetics , as well as new cartilage ,bone marrow and even new skin for burn victims. This tehnology is well under way and will put new tissues into bodies before the decade is out. By then , I reckon, transplant science will be capable of growing entire homogeneous organs, such as skin ad liver. In fact , the term transplant will be supplanted by the term tissue replacement .by the end of the next decade we will likely have entire complex organs available organ replacement. Until then ,true transplants will continue and broaden to include almost every organ in the body , except perhaps the brain itself.
The german school of psychology , gestalt hlds that in human experience , the whole is greater than the sum of the parts. In the not –too distant future , we may be exploring this in a physical sense as ultimately , we gain the ability to replace all our individual parts. If even our brains could one day be replaced , with a suoercomputer storing all our brains engrams which are then downloaded into the new brain , what is left that is truly us? Such a development might be the impetus for new branches of psychology and philosophy: what does it mean to be alive if there is no need for death?
Inorganic replacements will also progress as we learn more aout the functions of our bodies tissuses and organs. We already have devices and treatments for our special senses : for the eyes , we have glasses contacts control reshaping for the ears ,we have hearing aids and cochlear implants. Soon we will be implanting microsprocessors into faulty eyes and ears allowing the blind to see and the deaf to hear. We will also be producing artificial limbs that work very much like our own .by the year 2010 we will have a true six-million dollars man and that might well be the cost too.there are great problems facing the men health taking medicines alcohol injections but problems remain same for ED . men cant satisfy their women now we have penile implant and solved problems .in future scientist trying something more exciting to discover to solve erection problems .in 2015 there will be elixir of life for mens eections problems and reejaculte prostate cancer surgery able to birth baby now not.
Inorganic replacements will also progress as we learn more about the functions of our bodies tissuses and organs.we already have devices and treatments for special senses, for the eyes , we have glasses , contacts corneal reshaping for the ears we have hearing aids and cochlear implants .soon we will be implanting microprocessors into faulty eues and ears allowing the blinds to see and the deaf to hear. Erection for penile implant .we will also be producing artificial limbs that work very much like our own by the year 2015 we will have all handsome man and women.

However,late 2001 , a private company in worester Massachusetts called advanced cell technologies stunned the world when it created the first human clone. Although the embryo only grew to a microscopic ball of a few cells the experiments proved that human cloning is possible , and opened the doors for some much –needed scientific and ethical debate.
On july 31 , 2001 the US house of representative passed bipartisan legislation baning human cloning . the vote was 265 to 162, hardly a landslide.
What this suggests is that , even at the highest ranks of government , a lot of powerful people think human cloning is not a bad idea. Although I understand their rationale the potentiall to replace a lost child or create another Einstein or simply the freedom to expand human knowledge -I personaly think they are misguided. Human cloning is bad idea fraught with profound social and ethical implications . I figure that if we want to make more humans , do it the old fashioned way besides its farr more fun.

 

A company named geron has patents on six lines of stem cells ,but it also has somethings else in the works , geron is greek for oldman, suggesting exactly what this compny is investing aging.
The average human lifespan is now about 80 years in developed countries. That’s about how long an average set of genes will keep you going. Researchers at Harvard medical school recently conducted a genomic analysis of 137 100 year olds and found that they different from the general populations with respect to only about 10 genes found on chromosomes four. These genes it seems helped their carriers fight off many of the diseases related to aging heart diseases cancer dementia osteoporosis etc. one of the most encouraging conclusions one can draw from that research is that there are probably a few common mechanisms underlying those diseases.
One such mechanism seems to be an enzyme called telomerase, patented by geron. A telomere is like one of those plastic bits on the ends of shoelaces to keep them from unraveling caledd aglets for you trivia buffs it stops the chromosomes from unraveling and fraying at their ends. But telomerase prevents that from happening . the enzyme isnot contained in mature cells but is found in cancer cells. There it appears to contribute to the relative immortality of the cancer cells. In theory if we could introduce telomerase to normal mature cells or perhaps activate the gene that codes for it , we could achive immortality pone de leons fabled foiuntain of youth.
WE SCIENTIST TRYING TO KEEP THIS LOOKS FOREVER.

BIOTECHNOLOGY AND FOREVER YOUTH LIFE IN NEAR FUTURE 2026

Although the study of telomerase will no doubt provide some interesting answers to our questions about the aging process , I don’t think we will be putting telomerase in the drinking water anytime soon. So far we understand far too little about how it works . we are. However discovering the role that many hormones play in aging. If we can create such hormone or control the aging hormone, probably we will solve aging problems and people will looks forever young.this heavenly change can be happen anytimes.it not means they will not die they will die definitely. In particular human growth hormone and dehydroepiandrosterone have been investigated with respect to changes in body compositions .evidence indicates that these and other hormones might help to show the aging processs by keeping our bodies stronger and healthier longer . combine this with improved methods of detecting preventing and treating diseases and its hard not to conclude that children born in the late 1909s can expect to live to see the 22nd century
Today a montreal company called nexia biotechnologies among a few others ,is combining the genes of two organisams to produce useful products. Although they don’t look quite as horrifying as the mythical greek creatures and to the best of my knowledge, havenot made any demands for youths or maidens these transgenic animals are similar in concept. For example , nexia has produced heards of transgenic goats and cows which have the genes for specific proteins from other organisams spliced into the genomes of their mammary glands .as results the milk they produce contains those proteinds it includes spider silk to make nexia’s structural products biosteel and its clot –busting protein tissue plasminogen activator . nexia has also entered into a joint venture with a european biotech to develop trangenic cows that will produce a host of therapeutic proteins.
I think this is a great idea and feel it will continue to evolve and progress. Why not take advantage of what mother nature has provided ; cute little protein factories ? you might think it cruel but in fact the goats are very healthy and happy and once you havest the sought after protein you can even use the milk more goat chese for everyone/ it seemslike a more cost effective way of producing therapeutic proteins than huge bioreactors full of nasty bacteria requiring considerable maintenance . with the goats ,once have inserted the gene , you just let them out into the back forty to graze. Their bodies are better designed to make proteins than any laboratory. We could ever hope to voncoct.
Among the most important changes we will see in future will be the information that the medical community will be ale to gather about patients and the way in which that data is analyzed . in that light biotechnology and information technologies will combine to provide physicians with broader and more profound knowledge about their patients .part of this will occur in the near term , as new imaging system allow doctors to peer ever more accurately inside the human body without the need for surgery. Three –dimensional holographic reproduction of a patients inner anatomy for example ,the brain will be used to plan and practice surgeries before the patients is admitted. During the procedure a huge array of sophisticated robotic tools will allow the surgen to conduct her work from outside the operating theater to limit possible contamination through a few tiny incision, the patients recovery time will be reduced to a few days or even hours.
Computer are now and will continue to be used for national drug design. This process employs computers in two ways by comparing the structure of proteins targets to known protein structures, it can be used to determine the molecular function of disease related proteins
Second by manipulating computer manifestations of proteins dugs can be computer –designed to bimd to specific structure and have a predetermined effect. Drug design can also be optimized by identifying and guiding the sunthesis of newr better therapeutic compounds.
Genomics and information technology are now combining as bioinformatics , allowing individuals genomes to be deciphered and compared to large genomic databanks. This will allow physicians to determine any exixting or predisposing genes that might cause problems and to address them before the problems arise. Medicine will shift from being reactive to proactive , focusing on preventing disease rather than treating it. Drugs will be tailor –made for the individual, by accounting for individual difference in absorption , metabolism and efficacy. Rather than using a hit or miss strategy for determining which drug works best for a patient. Physicians will be able to determine that answer inadvance and prescribe the single best drugs for that person. In drug traisls , a similar approach will be used to pre-screen potential candidates best suited for trial thius limiting costs and improving the quality of the data gathered. For some time now , Japanese scientist have been working on tiny, even microscopic machines that might be introducd into our bodies to deliver drugs to specific locations or accurately carve away atheroseclerotic plaques from our arteries . one day we might see entiter surgeries performed by intravenously introduced robot teams, which would be directed by physicians who never have to enter the body. These tiny machines would be conceived manufactured and directeddd by computers.
And lets not forget about DNA computers .scientist at lucent technologies have theorized that the particular electrical properties , structure and stability of DNA make it an excellent candidate for a semiconductor . david smith of thechnology futures , an Austin ,texas technology forecasting firm , was recently quoted as saying we could have DNA computer that matches the power of the human mind by 2020.
Furthermore , because of the smallness of DNA molecules microprocessors now the size of postage stamps could be shrunk to microscopic proportions . obviously this would mean that computers could be smaller, but would also provide an opportunity to use these bioprocessors inside the body as adjunct or replacement .our physiology could be monitored and output to medical databanks that would alert us, and our physicians of any medical problem that arises .some day we just might be able to add memory to our own brains and increase our computational ability.
Example that anthrax and ost count of how many headlines included that word. It has come symbolize a new frighting reality in human evolutions . for the first time, we are forced to contemplate the possibility that huge chunk of the populations might be wiped out by biterrosm. This is a nefarious and insidious form of war fare, potentially horrifying effective. And anthrax is only one many possible agents that could ne used to wreak havoc ao our society.
Although the method is new the outcome is not .humans have ,in the course of history. Endured many plagues , both bscterial and viral /in a sense our greatest enemy has been mother nature herself.
Many microbial threats exist in our environment. Its important to remember that whiles a few people have died . albeit tragically from exposure to the anthrax bacteria .more have died when agricultural runoff gets into municipal water supplies and as result e. coli bacteria infect hundreads. Remember, too that about 20,000 people die each year from the flu. Worldwide , 47 million people have been infected with HIV/AIDS, 21 million have died and another 36 million are still infected.
For years now I have been predicdicting that about one third of the worlds population will be wiped out by a contagious microbe within my lifetime. On my side is Stephen hawking who recently predicted that the entire human race would be eliminated by the end of this millennium. That seemingly morbid pessimism aises from the fact that mother nature is much strognger than we realize ,and we are not nearly as strong and clever as we think.everytime we humans think we have conqured an infectious disease , another nastier one appears.
Prime candidates as causes of the next global plagues are both viruses influenza and eboloa and now 2000 is covid 19. It is estimatedthat in the early part of this century and now about one third of all human were infected with a particularly deadly strain of influenza . twenty million people diedfrom it.the corona virusdied morethan one billion of people may be more still people will die nobody knows how many days this vaccine will work but still chance to due many people. This virus will be never be vanished it is still with us if immune system will weak the virus will will attack us again.this virus mutates with regularly and every few decades a very deadly strain arises .this will without doubt , happen again, in fact we are overdue for it.
Ebola by contrast has killed only a few hundread people in its half dozen or so outbreaks . what is frightening is the lethal power of the ebola virus the worst strain killed 90 percent of those infected.so far the only strain to kill human are passed by direct contact with the body fluids of the infected individual.and the virus kills within day.although horrifying that characteristic has actually saved us, because the virus is too hot. It kills its victims before it can be passed on to very many people and burns out quckly once contained.
My fear is that an airborne version of the deadiest stain will evolve and will have a slightly longer latency period . by exploting our capacity to travel rapidly around the glove .the virus could easily infect billions of individuals within a few months.
Biotechnology can certainly help us here. Many biotechs are working on new antibiotics for bacterial infections , they are seeking antiviral products for disesase such as HIV/AIDS influenza even ebola even covid-19 . because microbial diseases mutate and evolve so quckly finding cures for them is like shooting at a moving target. Biotech are also investigating methods to boost our own natural defense system .a combinayion of those two biotech thrust will likely make infectious diseass less of global threat than it is now but I doubt we will ever win that war pnce and for all.
In solving problemswe should have strong leadership in the world.all world leadership has failed to solve all worldy problems ,we need hardworkers true leadership.here I want to mentions lot of countries have bioterrosiams and bacterial weapon besides other chemical and other weapons to kill humanbeings for theireown countries and economic intentions.actually chiana wants to create such virus or bacterial weapons and thus they tried to create corona virus in theire own laboratory. President trum is a patoritic president for USA. He tried hard for his own life to brings economic welfare to USA and he did it. He is right this is not covid-19 this is chaina -19 who destroy lot of lifes.so he said this is not covid but it is chiana -19.chaina wants capture whole world by there bioterrorizam through covid-19.lot of immigrant intellectual peole inside USA living with hardship and serving USA without looking them USA brings lot of refuses without skills paying lot of money fo them without reasons president trum said please make America great but not to brings and giving welfare without reasons.make first USA great then you tthink to whom you will give immigrations.anyway this is politics not to politices country but to make great country and it will solve the all problems invest money where you need but not to invest were nothing will brings and will brings lot of sufferings.

 

A new study suggests that former President Donald Trump’s inflammatory rhetoric around the coronavirus, which is believed to have originated in China, helped spark anti-Asian Twitter content and “likely perpetuated racist attitudes.”
The Asian American community has experienced a striking rise in incidents of hate since the onset of COVID-19, according to officials and advocates, and critics say the former president’s repeated use of “China Virus” and other terms helped fuel an environment of hatred.

“Anti-Asian sentiment depicted in the tweets containing the term ‘Chinese Virus’ likely perpetuated racist attitudes and parallels the anti-Asian hate crimes that have occurred since,” said Dr. Yulin Hswen, an assistant professor of epidemiology at UC, San Francisco and the study’s lead author.
The results, published in the American Journal of Public Health, come in the wake of a string of attacks on Asian communities in the U.S., including a series of shootings in Georgia that left six women of Asian descent dead.
The study indicated a difference in anti-Asian sentiment when using neutral hashtags such as #COVID-19 versus racist hashtags like #Chinesevirus — 20% of the hashtags associated with #COVID-19 demonstrated anti-Asian sentiment, compared to 50% of hashtags with #Chinesevirus.

former President Donald Trump addresses the Conservative Political Action
Dr. John Brownstein, an ABC News Medical Unit contributor and author of the study, said that such online conversations can spark violent reactions.
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“We often see that online conversations that contain messages of hate don’t stay online,” Brownstein said. “Oftentimes, the conversations that take place on social media results in real world consequences.”
Dr. Daniel Rogers, an expert on misinformation at New York University, said that hateful content on social media can lead to more of the same being served up to users via platforms’ algorithms.
“As platform algorithms pick up on engagement around this toxic content, they recommend increasingly more extreme content to users until their feeds are dominated by nothing but the most extreme stuff, goading those users with a propensity toward violence to potentially committing hate crimes,” Rogers said.

Researchers also found that the timing of the former president’s tweet was significant. The first time he used “ChineseVirus” was March 16, 2020, and the following week saw an increase in anti-Asian hashtags and a rise in hate crimes.
International health officials purposely avoided attaching geography to the virus, as had been done in the past, to avoid casting blame, but Trump insisted on tying China to COVID-19 at every turn.
Experts and policy makers warned against using inflammatory and racist tweets since they can serve as a rallying cry for hate crimes.
“Don’t attach locations or ethnicity to the disease, this is not a ‘Wuhan Virus,’ ‘Chinese Virus’ or ‘Asian Virus,” the World Health Organization wrote in a February 2020 bulletin.
In a wide-ranging press briefing on Wednesday, Biden administration press secretary Jen Psaki said that damaging rhetoric from the prior administration led to “inaccurate, unfair” perceptions that threatened Asian Americans.

One year ago, at the start of the pandemic, Trump condemned xenophobic attacks against Asian Americans, but he continued to use incendiary rhetoric and deny doing so was racist.
On the night several Asian women were shot dead in Atlanta, he referred to COVID-19 as the “China Virus” on Fox News.
The Trump Organization did not immediately respond to a request for comment from ABC News.
Hswen said it’s more important now than ever for our leaders to use neutral language because inflammatory words can influence people’s behavior toward particular groups.
The study results, Hswen said, “confirm that nationality, race, or ethnicity should not be attached to disease nomenclature, as these names can carry pejorative connotations that can stigmatize these communities.”

Anyway certainly many ethical issuses surrounded the commercialization of biotechnology . I could wax poetic for many works on this topic but that is not the purpose of this work.
However , some ethical isuses also have both commercial and global implications.
I am fascinated and amazed by what biotech has achived in a very short time. Soon diseasewill become more of an iconvenience than a threat to our survival. The problems is that , initially at least these technologies are enormously expensive . as noted earlier in this work .
Economics of scale will lower costs overtime as biotechs ramp up their production but that will bee a slow , steadly process . meanwhile how do we best make use of biotech products to ensure they benefit humanity.?

Here I like to mentione one Bangladesh eminat Islamic scholar named ALLAMA MUFTI HAFEZ MOULANA IBRAHIM

The pathways of history, the people of Bangladesh have gone through natural disasters, political turmoil, and man-made catastrophes. In response, they have fought, resisted and survived using their resourcefulness. Traditional cultures in Bangladesh have always been used as a way to increase spiritual and mental strength, as well as nourish the resourcefulness needed to face problems in everyday life such as covid -19. Mufti Ibrahim warn and request follow up quaranic sciences and Muhammad SWS prophesphys medicines you would be safe from corona virus.

said when corona appears that more millions people will die in world and specially he mentioned amoung the worlds population ,more INDIAN people will die more for covid -19.and it was happened last march april 2021.and his prophesy was fulfilled but worned INDIA be careful but nobody belives him but alas it was happened.and it is true that Bangladeshi primeminister follow the rules and Bangladesh was safe thufg Bangladesh is neigbouring country INDIA.
Honestly speaking ampung my neigbour hood and also people from Bangladesh ,Russia, Pakistan and india lot of people knows me as a microbiologist virologist and immunologist when corona pandemic rok out they asked me dr. shelley what we can please advice us:
I ty to advice them maintain cleanlessness if affected please mind more cleanness washing clothes use new cloth when you are outside and clean your body with warm water and clean your body with white towels and drink hot warm wateror lemon or orange juice and give air to your nose with hair dyier and take warm water vapor
And drink moring 5 ml olive oil and then after breakfast take black seed oil 5 ml and evening take 5ml coccount oil . and make paste with muster oil leaves Padina leaves making paste with master oil and eat with bashmati rice or kalizira rice. Eat 3 times a day .
Before sleep drink a cup of milk with pure honey .this is prophetic medicines and eat green pumkin curry with green chilly.
Peole listen to me and recover from covid and said thanks to me.many people by this traditional ancient formulas.so biotechnology also can make such a syrup with applying modern sciences.
Belive me lot of people saved by doing that still people taking my advices.and I publishe this thing in evening Bangladesh news paper named: experimental value and aseptic technique articles beginning of the year.

It is true that prime minister hasina is the mirror , creating Bangladesh is Golden Bengal.she is the only rightest priminister and true leader for the Bengali nations.
However whatever and how it happened but now we need to increase our biotechnology research to STOP Any pandemic that is going to attack us.now we have to think about the following 3 doctorine.all people can be united under this following banner problems will be solved
I.ONENESS OF GOD ALLAH(TAHID)
II. BELIVE IN ALL PROPHETS ADAM TO JESUS PEACE BE UPON HIM AND THE LAST PROPHET OF GOD ALLAH Muhammad SWS (RISALAT)
III. JUDGEMENTS .THE DAY OF JUDGEMENT
If you belivers you will never be bad persons brings belive in rerigion your hear will be clean and the body will be safe from any diseases and but we have to research to invention a new method following biotechnology and discover new drugs and methods. And world leadership should be perfect and true and actionable to their responsibilities.
If GOD will close the door of miracle(HEKMOT) but sure HE will open the door kindness and forgiveness(RAHMAT)
GOD gives us knowledge and brain by using is through technology we can solve thousands of problems.
Anyway,the governments or health plans of most wealthy countries now pay many biotech products but costs typically run in the tens of thousands of dollars per year. How long can this go on. Eventually each of us will probably benefit from one or more biotech products , so who is going to foot the bill. My sense is that ,over time , biotech products and services will actually save society a great deal of money by preventing disease and reducing the need for hospitalization . in the meanrime , only wealthy countries will have access to most of its products.
But what about the third world? Already in some African countries, HIV/AIDS infected about one third of the population. The drug cocktail that keeps sufferes alive here is far too expensive research is over, we could ,if we had the social and political will, provide the medication to everyone. The problem is that if we did , dug companies would be out of business very quickly .the question then becomes . is there a public will to provide drug at price that reflects only the cost of for people there to afford. As already mentioned , much of that cost is eailized during drug development the cost of production itself is often a few cents per pill. We currently extend legal patent and pice protection to dug compaies sothey can recoup their development costs and realize a profit but once the rsearch is over we could if we had the social and political will, provide the medication to everyone. The problem is that if we did drug companies would be out of business very quickly . the question then becomes , is there a public will to provide drugs at a price that reflects only the cost of production to developing nations, while charging our own citizens full freight? Whaat would stop the unscrupulous from simply buying the drugs abroad and resellings them here? I must confess I don’t forceses an easy solution to these problems .but in the end we should do whats best for the most people over the long term.

The way we think about drugs will change in the coming decades . very soon instead of getting a flue shot by needele , we might have the vaccine blasted into our system by a non iinvassive jet mechanism about the size of a lipstick container . after all. Sticking sharp metal objects into your body is not such a good idea . each year in north America , there are 600000 to 800,000 injections related accident ,resulting in litigation costs totaling hundread of millions of dollars . also , while injections are good at introducuing drugs into circulations they are not particularly good at maintaining the desired effect over a long period of time. Anyone who has been to the dentist has a good fell for this –pun intended.in the future we will see increasing use of inhalers , especially to deliver gene therapies . today’s orally imgested capsules and tablets are limited in effectiveness by absorption and metabolisam and can cause digestive problems and other side effects . orally ingested capsules will still used for some time , but increasingly these will contain large organic compounds that are asorved from our digestive tracts in tiny fat droplets.some drugs will be introduced into the system more slowly and evenly using patch technologies similar to todays nicotine patces . many drugs . including vaccines ,will actually be produced in common foods such as bananas and potatoes . I call these pharmafoods instead of taking a pill everyday, you would eat a speciall banana once a week and it would taste the same as always. We are already seeing calcium enhanced and vitamin enhanced orange juice . that is just beginning.
The future looks extremely positive ideed for the biotech sector / already at the time of writing just a few months after the events of september11 as they have become universally known the biotech index sits at 811 , some 19 percent above its low of 681 on September 19 two days after the markets reopened . as I have said many times in public and private biotech will lead the way out of the bear market , sometimes that has already stayed. If yu follow the strategies set out in this work the next five or so years should be very profitable for you and me too. Society wins as well , since our financial success is predicted on finding cures for diseases.
I wish I could assure you that everythings will be coming up roses but that would be mialeadings.
We will also witness , I asure you turbulent times .as the markets rebound trillions of dollars will begain to pour out of fixed –income investments and back into the markets. This is simply a matter of personal and institutional wealth and the size of the economy. First , remember that the bond markets hold ,on average about ten times the capital invested in stocks. Bond markets do well with falling interest rates. I know this seems country, but think of it this way , would you want to buy a new bond at two percent, or a bond someone else has been holding that pays five percent bonds are commodities like any other and as interest rates fall , those held from past investment that pay more become more valuable . of course the opposites is true too. As interest rates rise ,new bonds become more attractive . so old ones are sold off. At tha same time , stocks usually rise due to the favorable investment climate and the increase money supply brought on by low interest rates. Interest raytes fell 11 times in the year and at a 40 year low of 1.75 percent , they cant fall much frther . the only way out is up.
What all this means is that ,in the near ftre , money will pour back into the stock markets as the broader economic pictre improves . this will provide pward pressre on biotech share pricess and open the window for new financing . biotech will grow bt alas I fear it will at a rate too high to sustain. Psychology plays a large in investment and markets are self –corecting ,not efficient . I say this with confidence given that the 2001 nobel prize in economics went to two economics who are of like mind on this issue . therefore ,like a swing set in motion , the biotech sector will experience a number of boom and bst cycles with diminishing highs and lows , although the overall long term trend will definitely be up. Eah time a major breakthrough hits the media , hungry investors will bite at anythings that looks hot.
Now I like to say somethings alse .see Bangladesh as a example .the state secretary USA dr. henerry kisinger said looking at the csituation of poverty in Bangladesh in 1971 said Bangladesh is is the bootmless basket but now you see at Bangladesh is in some comparable with Europe and other developed country is the most developing even some extend even better than developed country.it happended not due to time but the efforts of Bangladesh peoples and and the government government of prime minister sheikh hasina .in 1971 babgladesh cant produce even pain killers but now bangladsh producing large number of varieties drugs medicines is quality is keeping up even USA.

See Bangladesh garment industry one is most famous industry in the world .all over the world has great demands.crime hatret everythings is under control of government making savior punishment rules to control thieves robbery and rapes and killings .and beautification Bangladesh is going on villages and cities using electirification and digital Bangladesh. Even government controlling red light districtic women and children ,making the special areas to live and controlling them to giving them job offers. No description on Hzra women and prostitute women special places and controlling them with sanitary hygienic condion and creating for them work.taking care their elderly men and women and children and suffering peoples . creating villages with making high land to save them from flood.taking care of rivers creating good roads both sides of the rivers.everyday new houses is going to blid to give people proper shelter .agricltre sector developing to grow more crops and foods fruits and vegetables usining biotechnology cattles and animal sciences are developing. Babgladesh GDP is higher than even INDIA and Pakistan and it is comparable with developed countries.health care are under care of governments lot of government and private health care system are developed .studies and research are going up day by day. Now women education is hire than any other country. Most of women are highly educated than men.and getting gold medals due to exvelence studies. Most of Bangladeshi and now orking in outside the country with the prestize positions and became famous lot of Bangladeshi people working hard in aboad and bringing lot of remittance for Bangladesh.

inpeace in this year.
However,
But mainly we need to discover new drugs for solving disease problems in human being through the using biotechnology we have already seen this happen as a result of the anthrax scares. Biotechs that research or make anythings to do with pathogens diseases causing microbes have jumped significantlywe know Cepheid which makes equipment for genetic analysis of pathogens ,up 131 percent bioreliance a maker of smallpox vaccine up 129 percent nanogen which has a contract from the USA army to develop chips that detect biwarefare pathogens up 92 percent all within five weeks of September 11.
All that looks like great news for investors and if they were savvy enough to get in on September 17and sell today , they have reason to gloat. But it makes me nervous . it tells me that many traders are wiliing to jump into the markets ahead of the investors , looking for so called easy money. If a companys shares rise 131percent in five weeks , how likely is it that such explosive growth will continue ? if it continued for 12 months , cepheidwould grow from a 300 million dollars company to about a 300 billion dollars company in a year making it one of the worlds largest . as George bush sr. would say not gunna happen .what will more likely happen is a precipitous drops in price and you sure don’t want to be buying just before that occurs .today only four days after Cepheid hits 52 week high of 11.48 accounting for the 131 percent noted above ,it traded as low as 6.70 , a 42 percent loss if you were the poor sap who bought in at 11.4 dollars.
Traders like that kind of volatility , especially furthers traders . but if you are , as I trust you are an investors , times like that can be unnerving indeed.
As much as rash of drugs approvals might send biotechs storming up. A rash of bad news will send them right back down again with equal velocity . like roller-coaster lovers , you need a strong stomach . eventually , as the sector matures further . these precipitios hights and lows will even out like the ever diminishing rings that extend from a rock thrown into a pond.calmer heads and smother times will prevail.
My recommendations for investors is to avoid over –managing or over analyzing . buy in, make reguar contributions and sell if and when the time is right . keep a careful eye on things, but whatever you do , don’t panic . no stock price goes straightup forever. If there is a precipitous rise and ypu own shares , sell. You win.
Bad things happen . sometimes they are bad things on a massive scale, such as the events of September 111 , or the 1995 earthquake in kob , japan , which killed 5000 and in part triggered the asian economic meltdown.sometimes they are on a smaller scale , such as failed clinical trial , an economic sowdown or the failure of a business plan. What is important is that we keep a reasonable perspective . expert the best, but prepare for the worst. Sad to say , history shows there will always be more wars , more deaths , more tragedy but in the long run things are never quite so bad as they seem at th time. There are no sure things in life. For example , I am going to a hockey game tonight with to watch my favorite teamthe .or to watch cricket . someone might fly a plane into general motors place or put anthrax or corona virus into the ventilation system but the odds are pretty good that they wont am I concered?
A tiny bit , I confess . will it stop me from going to the game not a chance if I don’t go the terrorist win life must go on Go said biotechnologist David.

If primeminister Hasina want to make Golden she should go through biotechnologist and ordered her countries pharmaceuticals company to invest in biotechnology.ther is key to make Bangladesh to golden bengal dreams of Bengali father of the nation bangobhandu sheikh mujibur rahman.

Now about agricltral biotechnology :
I submitted at the UNU –IRRI WORKSHOP ON NITROGRN FIXATION IN THE RHIZOSPHERE OF RICE.
Ther were , 15 proposal my proposal was top of the list ,it brings lot of signicanse in the al the projects. There were my name is the top of the list please see the book and edited by me,TO ATTEND THAT WORKS AMOUNG ALL SOVIET SCIENTIST I WAS SELECTED TO JOUN THAT WORKSHOP
There were DR. W. T. TUCKER RESEARCH SCHOLL OF BIOLOGICAL SCIENCES, AUSTRALIAN NATIONAL UNIVERSITY CANBERRA, AUSTRALIA .DR. S.K LEE INSTITUTE OF AGRICULTURAL SCIENCE ,MINISTRY OF AGRICULTURE AND FISHERIES SUWEON KOREA.
DR. WANG , F,
INSTITUTE OF BOTANY CHINESE ACADEMY OF SCIENCES BEIJING , CHINA.
DR. J.R. MILAM DEPT OF MICROBIOLOGY AND CELL SCIENCE UNIVERSITY OF FLORIDA GAINSVILLE . USA.
DR. JARYA BOONJAWAT DEPT OF BIOCHEMISTRY CHULALONKORN UNIVERSITY BANGKOK THAILAND.
DR. A. ADELAYO FACULTY OF AGRICULTURE UNIVERSITY OF LIFE UNIVERSITY OF LIFE ILE NIGERIA.
DR. A.P RUSCHEL CENTRO DE ENERGIA NUCLEAR NA AGRICULTURA CENA SAO PAULA BRAZIL. DR Y. DOMMERGUES LABORATORIES DE MICROBIOLOGIC DES SOLS . O. R.S.T.O M DAKAR SENEGAL
DR. S,A KULASOORIYA DEPT OF BOTANY UNIVERSITY OF PERDENIYA PERADENIYA SRI LANKA.
DR/ I. WATANABE SOIL MICROBIOLOGY DEPT IRRI COLLEGE LAGUNA PHILIPPINES
DR. M. UMALI GARCIA COLLEGE OF FORESTRY UPLB COLLEGE LAGUNA PHILIPPINES .
DR. J. BALANDREAU
CENTRE DE PEDOLOGIC BIOLOGIUE DUE CNRS.VANDOEUVRE CEDEX FRANCE.
DR. Z SHAMSUDDIN DEPT OF SOIL SCIENCE UNIVERSITY OF PERTANIA SELANGOR MALAYSIA. AND DR. K.A AHMED GENETICS DEPARTMENT FACULTY OF AGRICULTURE , CAIRO UNIVERSITY EGYPT.
I worked amoung with above mentioned scientist .all were distinguished scientist it was pleasure to work with them in theaae field e together developed biological nitrogen fixation and it brings lot of significances in agricultural biotechnology.
Key points:
1. The united nations university is organizing a workshop on nitrogen fixation in thee rhizosphere of rice which will be co –sponsored and hosted by the international rice esaerch institute , ls banos , Philippines 28 april -4 may 1984 . the overall aim of this worshop is to established a neork of institutions cooperating in this fiel of research
2. The purpose of this letter invitation to invite me dr. shelley to participate in the workshop. First . let me dr. Robert kokke senior program officer development division .in the scope of its commitment to strengthen the biotechnology research capacity of institutions in developing countries , the UN university is working to establish a co-ordinate research projects on nitrogen fixation in the rizosphere of rice still that work going on and implemented IRRI and brings lot of economic welfare to the developing country.
3. As know it is well –known that rice is thee stable food of three –fifths of the world populations and that high nitrogen inputs are required for good yields.part or possible all of this nitrogen requirement may eventually be met through biological fixation of nitrogen from the atmosphere. Researchers at the Japanese national institute of geneics under the leadership of Dr. Y ukinori Hirota have found some ricee strains which haveee a capacity to use nitrogen fixed by microorganisams living in the rhisosphere . they are now attemting to transfer this capacity oto high –yoelding cultivars.and Former USSR Dr. sil shelley and profeeesor DR OF SCIENCES V.T EMTSEV FOUND ANAerobic acteria genus clostridium to fix atmosapheric nitorogen see his articles and dr. shelley was invited in same year to attended to Bangladesh crop response correlations studies and his research work anaerobic nitrogen fixing bacteria genus clostridium was very much acceptable and his suggestions was accepted publishe in news paper Bangladesh observer and paper was published in book .in conference proceddings in first pages crop response correlations studies pleae see attached documents.the approach is multi disciplinary , involving molecular biologies , plan breeders soil scientists and others.
4. It is happy to say .the UN university has chosen to work on biological nitrogen fixation for several reasons. The research will be ofimmediate importance to developing countries. The results of this research are more readily available since it is carried out primarily in institutions rather than industrial laboratories . by catalyzing a greater interest in this field in developing countries the UN Universities hopes to create core groups of researchers which will then have the capacity to deal with other topics in the field of biotechnology.
5. A modest amount of the UN University funding has been allocated to this project for research support, fellowship award and communication of results .dr. Hrota is very co –operative and willing to ecive a nuber of post graduate or post doctoral scientists from developing countriesto work with him in his laboratories. Other advanced laboratories where scholars can participate in the research are invited to do the same. The visiting scholars should spend a period of six to twelve months in the host institutions.the host institutions are entitle to receive a compensation for their costs. More experienced scientists from developing countries may be supported t make scientific visits of one week to three months to other laboratories participating in the program. Consultants may also be hired fot specific missions small sums of money may be used to strengthen research in certain individual discissed by the participants . as a participant we performed all task and implemented to the developing country still today there are lot of crop response.
6. Dr. Robert recognizing my expertise and expeience in this field and dr. rober rober kokke said to me he would like to invite meed me in several workshop to discussed with him about the nitrogen fixing bacteria to participate in this and various workshops or to propose a qualified substitute if I dr. shelley cant not atten but I attended in netrland UK FINLAND ETC. and that will be a highly technical worship comprising esearchers working in this field a ist of the specific meetings objectives and provisional agends are enclosed the major activity will be discussions on the states of current research as perceived by the individuals participants and ideas for further cooperative efforsts.
7. i immediatel response with my research works and proposal see on the first my name dr. s.i.shelley dr,robert kokke would like to solicit a my proposal on some aspects of the topic that my feel to be of immediate importance the enclosed projects proposal form outlines the information that should be included .[roposal shuld prefeably be submitted in advance until 1 15 april 1984 ,they should be sent to dr. robert kokke in tokyo . thereafter they should go to dr. i watanae at irri , po box 933 manila philippines and it was done by me dr. si.shelley
8. please see to attend the different meeting the una universty wil provide economy class round trip tickets from my academy institutes to los banos plus per diem for the days of the conference to be paid according to the un standard. and i confired and work out.EXPLAINED BY DR. ROBERT KOKKE.
9.
10. After successfully projects completions sent me edited version of the recommandations of the UNU –IRRI workshops on nitrogen fixation in therizosphere ofrice held at IRRI , LOS BANOS , 28TH APRIL 3 MAY 1984
11. DR. ROBERT KOKKE wishes also to take this opportunity totanks me for participating in the workshop and for the valuable contribution which I made to it. And he hoped the workshop will be the beginning of fruitful co-operation of scientists in this areas
12. My suggestions and he mentioned in his letter I dr. shelley wishes me to to revise or ewrite my proposal to unu in the light of thr discussions and the ecommandations of the work and see please his appreciation letter and evetually i reedited andsubmitted to him .pleasesee enclosed book.
MY RECOMMENDATIONS WAS AS FOLLOWS: BIOLOGICAL NITROGEN FIXATIONS:
Conclusions
To have alternatives to intensive use of nitrogen fertilizers in the cultivation of rice ., it is necessary to explore the potential of biological nitrogen fixation in rice fields. Among the known system , rihizospheric nitrogen fixation has ben relatively underexploted. In view of this , the participants have agreed to recommend the establishements of a network of research in this aeaaas under the UNU program .aftr reviewing the current state of knowledge , it is fet that more fundamental research is needed before investing large amounts of money in field experiments the following aspects have been identified in which in depth studies are essential to have a clear picture of plant –bacteria associations:
1.survey of diverse rhizosphere ecosystems of rice for isolating and identifying

I.Active colonizers and
II. Aactive nitorogen fixers.
Remarks my anaerobic bacteria considers active nitrogen fixers
2. accurate and reproducible assessment of nitrogen fixation and colonization potential different isolates.

I made reoomendation and we together took following declaration.
i. To have alternative to intensive use nitrogen fertilizers in the cultivation of rice, it is necessary to explore the potential of biological nitrogen fixation in rice fields .among the known systems, rizosphereic nitrogen fixation has been elatvely underexplored. In view of this , the participants have agreed to recommend the establishmen of a network of research in this area under the UNU program
ii. Note: after reviewing the current state of knowledge , it is felt that more fundamental research is needed before investing large amounts of money in field experiments. The following aspects have been dentified in which in depth studies are essential to have clear picture of plant bacteria associations:
iii. A.}survey of diverse HIOSPERE of rice for isolating ad identifying
iv. B.active clonozers and ii active nitrogen fixers.

1. Accurate and reproducible assessment of nitrogen fixation and colonization potential of different isolates.
2. Accurate and reproducible assessment of the ability of rice cultivativars to benefit from biological nitrogen fixation.
3. The meeting also recognized the necessity to increase the capability of young scientists from developing countries to apply molecular biological techniques to rhizosphere BNF through training in recognized centers,
In this areas the meeting has stressed the necessity of adopting the following uniform methodologies to aarive at meaningful comparisions of the results from different laboratories.

• Isolations of strains
• The staring materials must be obtained from an actively fixing plant, as proven by aceetyline reduction and must include roots as well as adhering soil.
• Only very abundant bacteria are worth isolating as they are likely to be good colonizers.
• Dilutions of the starting materials can be inoculated to diverse media, including spermosphere models.
• Among underinvestigated groups of nitrogen fixing bacteria are mehane using bacteria , cellulolytic bacteria , hemicellulolytic bacteersa and actinomycetes.
• A great effort must be made to determine isolates using proper available methodologies.
1. Assessment of strain potential
2. It seems important to distinguish the potential for nitrogen fixation and the potential for colonization.
3. The potential for nitrogen fixation can be assessed using monoaxenic systems such as the spermosphere model.
4. Models closer to natural situations will be preferred if they show an atleast similar comparable reproducibility.
5. Reference strain common to all participants shall be included in such comparative studies for enterobacteriaceae it will be klebsiella oxytoca NG13 –NIF + , NIF _ pfr.
6. Hirotha and for azospirillum it will be A. lipoferum 34H from phr.
7. Watanabe.
8. Regarding the potential for colonization available methods counts, lectin rection , attachments measurements and microscopic observation must be evaluated and standardized before becoming routine methods.

• Assessment of rice cultivator potential
• Here again the spermosphere model can be used as simple routine procedure as long as allowance is made for difference in the size seeds. Whenever possible results must be confirmed by experiments on older plants using 15 nitrogen , this can be made by comparing cultivars to reference cultivars on the basis of their 15 nitrogen content either with uniformly labeled soil or using natural aboundance of 15 nitrogen if a soil is available with a hgh vaue.

Reference rice proposed are : oryza japonicaT65, cycle duration 110 days , oryza sativa IR58 , cycle duration 100 days m, oryza sativa IR42, cycle duration 120 days.
Detecting inactive lines seems as important as detecting very active ones . the former can become useful controls in further experiments.
In addition to rhizosphere biological nitrogen fixation , the meeting recognized the potential role of other process vesicular –arbuscular endomycorrhizae , growth promoting substances , other nitrogen fixing systems in relations to rice production which are beyond the scope of the proposed network.

Author: Dr.Sherajuli Shelley, Assistant Manager) D. MRSB. Candidate: Fellow of Royal Society Biology of the United Kingdom. Bactolac Pharmaceutical Accuon Labs Inc , NY. USA winder labs Winder labs.
email: drsishelley1@gmail.com

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